Effects of DuP753, PD123177 and Nifedipine on Adrenal Aldosterone Secretion Induced by Angiotensin II in Anesthetized Dogs
نویسندگان
چکیده
منابع مشابه
Stimulation of Aldosterone Secretion by Angiotensin II
The role of the renin-angiotensin system in renal hypertension has been investigated for many years but the relationship of the renin-angiotensin system to adrenocortical function has received less attention. In 1951, Deane and Masson,4 using the rat as an experimental animal, reported that encapsulation of the kidney, a procedure which results in hypertension presumably through release of reni...
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Many studies have implicated both angiotensin II (ANG II) and aldosterone (Aldo) in the pathogenesis of hypertension, the progression of renal injury, and cardiac remodeling after myocardial infarction. In several cases, ANG II and Aldo have been shown to have synergistic interactions in the periphery. In the present studies, we tested the hypothesis that ANG II and Aldo interact centrally in A...
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The effect of nifedipine, a calcium slow channel blocking drug, was investigated by varying routes of administration in a canine model of pharmacologically induced bronchoconstriction. Control bronchopulmonary responses, i.e., increases in pulmonary resistance (RL) and decreases in dynamic lung compliance were accomplished by aerosols of prostaglandin F2 alpha and histamine in normal pentobarbi...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1995
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)47024-8